PRODUCT DETAILS

About Methersafe Tablet

METHYLERGOMETRINE belongs to the class of medication called 'ergot alkaloids' or 'uterotonic' primarily used to prevent and stop heavy bleeding (postpartum-third stage of labour bleeding) after childbirth or after a miscarriage in cesarean section. Besides this, it is also used to improve uterine contraction (antepartum) and produce uterine contraction during the third stage of labor (postpartum). Postpartum haemorrhage is heavy bleeding (more than normal) after the birth of the baby. It generally happens when the placenta is delivered within one day of giving the childbirth.

METHYLERGOMETRINE contains a semi-synthetic ergot alkaloid 'Methylergometrine' given in the intravenous (IV) form or intramuscular (IM) form that stimulates uterine muscles and increases the uterus' contractions thus reducing the blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), increasing the contractions and producing labor. As a result, these increased uterine contractions help in the child's delivery and substantially reduce the excessive uterine bleeding. 

Your doctor will give METHYLERGOMETRINE before childbirth or during labor pain. Do not self-administer. The most common side effects of METHYLERGOMETRINE are nausea, vomiting, headache, stomach pain, mild headache in some cases. Most of these side effects of METHYLERGOMETRINE do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you ever had surgery of the uterus, cesarean, or premature labor, please inform your doctor before taking METHYLERGOMETRINE to avoid any complications. Also, mention all the other medications you are taking to affect the way METHYLERGOMETRINE works. If you have been given prostaglandins, then do not take METHYLERGOMETRINE as both medications, if taken together, can increase the contractions. A METHYLERGOMETRINE should not be used for a prolonged time if the contractions do not increase or have severe pre-eclamptic toxemia (high blood pressure, protein in the urine, and swelling), blood or heart circulation problem. 

Uses of Methersafe Tablet

Uterine haemorrhage

Medicinal Benefits of Methersafe Tablet

METHYLERGOMETRINE contains a semi-synthetic ergot alkaloid 'Methylergometrine' primarily used to stop heavy bleeding postpartum i.e. third stage of labor bleeding after childbirth or after a miscarriage in cesarean section. Additionally,  it plays a major role in childbirth by increasing the uterus contractions and induces labor in pregnant women. METHYLERGOMETRINE works by stimulating uterine muscles and increasing the uterus' contractions thus reducing blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), increases the contraction,s and hence induces labor. As a result, these increased uterine contractions help in the delivery of the child and substantially reduces the excessive uterine bleeding.
 

Directions for Use

METHYLERGOMETRINE comes in injection form and should be given by a professional healthcare professional under strict medical supervision. Do not self administer.

Side Effects of Methersafe Tablet

Nausea

 Vomiting

 Headache

 Stomach pain

Mild headache

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take METHYLERGOMETRINE if you are allergic to METHYLERGOMETRINE or any of its ingredients. Increasing the dose of METHYLERGOMETRINE can be harmful if your womb already has too strong contractions, any obstructions in the pathway that might prevent the delivery or if the baby is not receiving a sufficient oxygen supply. Also, use of METHYLERGOMETRINE is not advisable if the baby is wrongly positioned in the birth canal, the baby’s head is too large to fit through the pelvis, the placenta lies near the neck of the womb, the placenta separates from the womb before birth, the womb is over-extended and likely to tear (in case you are carrying more than one baby). If you have been given prostaglandins, do not use METHYLERGOMETRINE with 6 hours as both medications, if taken together, can increase the contractions. METHYLERGOMETRINE should not be used for a prolonged time if the contractions do not increase or if you have severe pre-eclamptic toxemia (high blood pressure, protein in the urine, and swelling) or blood or heart circulation problem. A professional should always administer METHYLERGOMETRINE at a hospital, do not practice self-administration. It should also not be given in the form of a rapid injection into a vein as it might cause hypotension (low blood pressure) or suddenly increased heart rate.

Drug Interactions

Drug-Drug Interaction:

METHYLERGOMETRINE interacts with METHYLERGOMETRINE so it should be used with caution with anaesthetics (sevoflurane, halothane, cyclopropane, desflurane), other medicines used to start labor (prostaglandins), anti-diuretic hormone (vasopressin), a neurotransmitter (dopamine), anti-sickness medicine (ondansetron), sympathomimetic agents (epinephrine).

Drug-Disease Interaction:

METHYLERGOMETRINE should not be given to the patients with previous cesarean section, hypertension (high blood pressure), heart problem, cervical cancer, herpes infection, kidney problem, if you more than 40 weeks pregnant or are more than 35 years age, the pelvis is too small for normal delivery.

Safety Advice

ALCOHOL

METHYLERGOMETRINE should not be taken until prescribed if you are taking alcohol. Keep your doctor informed if you drink alcohol

PREGNANCY

METHYLERGOMETRINE is used to induce contractions in the uterus so has to be given only by the doctor for delivery.

BREAST FEEDING

Take METHYLERGOMETRINE only when prescribed, as it is known to pass on in a limited quantity via breast milk to the child by is not known to harm the baby. Contact your doctor before using METHYLERGOMETRINE.

DRIVING

METHYLERGOMETRINE can cause contraction of the uterus and lead to baby birth. So, driving a car may be highly unsafe.

LIVER

METHYLERGOMETRINE is not known to show any interaction in liver disease. However, caution is required in females who are having mild or moderate hypertension.

 

KIDNEY

METHYLERGOMETRINE to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose will be adjusted by your doctor as METHYLERGOMETRINE can cause fluid retention if taken in the kidney.