PRODUCT DETAILS

About Denex Forte 450 mg/300 mg Tablet

Rifampicin + Isoniazid belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine, and bone marrow.

Rifampicin + Isoniazid is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin works by inactivating a bacterial RNA-polymerase) an enzyme that allows TB bacteria to make and replicate essential proteins. Isoniazid prevents the creation of its own protective coating by these bacteria. Together, they destroy the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis)., and the infection is eliminated.

Uses of Denex Forte 450 mg/300 mg Tablet

Tuberculosis.

Medicinal Benefits of Denex Forte 450 mg/300 mg Tablet

Rifampicin + Isoniazid is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin works by inactivating a bacterial RNA-polymerase) an enzyme that allows TB bacteria to make and replicate essential proteins. Isoniazid prevents the creation of its own protective coating by these bacteria. Together, they destroy the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis)., and the infection is eliminated.

Directions for Use

Take Rifampicin + Isoniazid 30 minutes before food or 2 hours after food. Swallow Rifampicin + Isoniazid as a whole; do not crush or chew the tablet. The dose and duration of Rifampicin + Isoniazid can vary depending upon your condition and the severity of the infection.

Side Effects of Denex Forte 450 mg/300 mg Tablet

• Drowsiness
• Dizziness
• Headache
• Weakness
• Muscle pain 
• Heartburn 
• Diarrhea
• Gas
• Numbness 

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug-Drug Interaction:

Rifampicin + Isoniazid may have interaction with anti-HIV (saquinavir, ritonavir), pain killer (acetaminophen, hydrocodone), and anti-depressant (duloxetine, bupropion), calcium channel blocker (diltiazem), anti-TB (ethambutol, pyrazinamide), and vitamins (ergocalciferol, cholecalciferol).

Safety Advice

DRIVING

Rifampicin + Isoniazid may cause dizziness, drowsiness, numbness, and tingling sensation in the hands and feet. Do not drive or operate machinery if you experience these symptoms.

LIVER

Dose adjustment may be needed.

KIDNEY

Dose adjustment may be needed.