PRODUCT DETAILS

About Daplo MF 5mg/1000mg Tablet

DAPAGLIFLOZIN+METFORMIN belongs to the class of 'antidiabetic drugs', primarily used to treat type 2 diabetes mellitus with a proper diet and exercise. DAPAGLIFLOZIN+METFORMIN also lowers the risk of heart failure in type 2 diabetic patients with heart diseases. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant to breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all. DAPAGLIFLOZIN+METFORMIN is not indicated for use in type 1 diabetes.

DAPAGLIFLOZIN+METFORMIN is composed of two antidiabetic medicines, namely: Metformin and Dapagliflozin. Metformin belongs to the class of biguanides and manages blood sugar levels, particularly in obese patients. It exhibits a nonpancreatic effect to reduce blood glucose levels without increasing insulin secretion. Dapagliflozin belongs to the class of gliflozins. It works by reducing blood sugar levels by eliminating excess sugars from the body through urine.

Take DAPAGLIFLOZIN+METFORMIN as advised by your doctor. Some common side effects of DAPAGLIFLOZIN+METFORMIN include nausea, vomiting, diarrhea, headache, weakness, runny nose, genital infection, dizziness, taste changes, and sore throat. Sometimes, DAPAGLIFLOZIN+METFORMIN can cause side effects like lactic acidosis (a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation) and diabetic ketoacidosis (excess production of blood acids (ketones)). These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor. 

DAPAGLIFLOZIN+METFORMIN may cause hypoglycemia (low blood sugar); hence it is advised to make healthy food with enough calories and avoid heavy exercise. Do not take or stop this medicine, if the doctor did not advise you to do so. Before starting DAPAGLIFLOZIN+METFORMIN, let your doctor know if you have any medical history of heart, kidney, or liver diseases, breathing problems, blood disorders, dehydration, alcohol use, low blood pressure, and yeast infection of the genitals. It is advised to avoid your alcohol intake while using DAPAGLIFLOZIN+METFORMIN to decrease the risk of lactic acidosis. DAPAGLIFLOZIN+METFORMIN is not recommended for use during the second or third trimester of pregnancy and breastfeeding.

Uses of Daplo MF 5mg/1000mg Tablet

Type 2 Diabetes mellitus 

Medicinal Benefits of Daplo MF 5mg/1000mg Tablet

DAPAGLIFLOZIN+METFORMIN treats type 2 diabetes mellitus and contains Metformin and Dapagliflozin. Metformin is a biguanide and manages blood sugar levels, particularly in obese patients. It exhibits a nonpancreatic effect to reduce blood glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. Metformin is considered a unique antidiabetic drug since it does not cause hypoglycemia (lowered blood sugar levels). Dapagliflozin belongs to the class of gliflozins. It works by reducing blood sugar levels by eliminating excess sugars from the body through urine. DAPAGLIFLOZIN+METFORMIN also reduces the risk of heart failure in patients with type 2 diabetes and heart disease. DAPAGLIFLOZIN+METFORMIN may be advised with or without other medications along with diet and exercise to control blood sugar levels. 

Directions for Use

Tablet: Swallow the tablet of DAPAGLIFLOZIN+METFORMIN as a whole with a glass of water. Do not chew, crush or break the tablet. Take DAPAGLIFLOZIN+METFORMIN preferably with a meal, since it lowers the blood sugar levels and may cause gastrointestinal side effects. Your doctor may start the course with a low dose and gradually maintain an effective dose to achieve the required blood glucose control.

Side Effects of Daplo MF 5mg/1000mg Tablet

• Nausea
• Vomiting
• Diarrhea
• Headache
• Weakness
• Runny nose
• Genital infection
• Dizziness
• Taste changes
• Sore throat
• Lactic acidosis (rare)
• Diabetic ketoacidosis (rare)

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Inform your doctor if you take other antidiabetic drugs so that the dosage of DAPAGLIFLOZIN+METFORMIN will be adjusted accordingly. Do not abruptly stop taking DAPAGLIFLOZIN+METFORMIN midway if the doctor did not advise you. DAPAGLIFLOZIN+METFORMIN may cause hypoglycemia (low blood sugar); hence it is advised to make healthy food with enough calories and avoid heavy exercise. Brief your medical history to the doctor if you have any heart, kidney, or liver diseases, breathing problems (asthma, obstructive lung diseases), blood problems like anemia (lack of blood cells), vitamin B12 deficiency, pancreas problems/surgery, dehydration, alcohol use, low blood pressure, and yeast infection of genitals before taking DAPAGLIFLOZIN+METFORMIN. Avoid alcohol intake while using DAPAGLIFLOZIN+METFORMIN since it may increase the risk of lactic acidosis. DAPAGLIFLOZIN+METFORMIN is not recommended for use during the second or third trimester of pregnancy and breastfeeding. Your doctor may advise alternate medications to control your diabetic condition in such cases. DAPAGLIFLOZIN+METFORMIN is not recommended for people younger than 18 years of age.

Drug Interactions

Drug-Drug Interaction:

DAPAGLIFLOZIN+METFORMIN may interact with water pills (hydrochlorothiazide), pain killers (ibuprofen, celecoxib), and drugs that treat acidity (cimetidine), asthma medicines, blood pressure-lowering drugs, and corticosteroids.

Drug-Disease Interaction:

Tell your doctor before taking DAPAGLIFLOZIN+METFORMIN if you have any heart, kidney, or liver diseases, breathing problems, blood disorders, dehydration, alcohol use, low blood pressure, and yeast infection of the genitals. DAPAGLIFLOZIN+METFORMIN is contraindicated in patients with severe renal impairment and metabolic acidosis/diabetic ketoacidosis.

Safety Advice

ALCOHOL

It is advised to avoid alcohol intake since it may worsen the side effects like lactic acidosis and increase the risk of developing low blood sugar levels.

PREGNANCY

Dapagliflozin in DAPAGLIFLOZIN+METFORMIN is not recommended during the second or third trimester of pregnancy. Your doctor may suggest other medications to control your blood sugar levels. Please consult your doctor before starting DAPAGLIFLOZIN+METFORMIN if you are pregnant or planning to conceive.

BREAST FEEDING

DAPAGLIFLOZIN+METFORMIN may be unsafe to use during breastfeeding since it is excreted into breast milk. Please seek medical advice for further information.

DRIVING

Your driving may be affected if your blood sugar levels are too high or too low. Do not drive or operate machinery if you also experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar.

LIVER

Let your doctor know if you have any history of liver diseases or hepatic impairment when prescribed DAPAGLIFLOZIN+METFORMIN.

KIDNEY

DAPAGLIFLOZIN+METFORMIN is contraindicated in patients with severe renal impairment/kidney diseases. Let your doctor know if you have any history of kidney diseases when you are prescribed DAPAGLIFLOZIN+METFORMIN.