PRODUCT DETAILS

About Proxzol 500mg/20mg Tablet

ESOMEPRAZOLE+NAPROXEN belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or pain killers used to reduce and relieve pain. Pain is a highly unpleasant physical sensation caused by illness or injury.

ESOMEPRAZOLE+NAPROXEN is a combination of two drugs: Naproxen (painkiller) and esomeprazole (antacid). Naproxen is an anti-inflammatory drug that works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body to produce certain chemical substances (prostaglandins) that cause pain and swelling. This helps reduce mild to moderate pain and inflammation at the injured or damaged site decreasing stiffness in joints. Naproxen has been reported to cause gastric discomfort, acidity, and risk of stomach ulcers. Hence, it is combined with esomeprazole (proton pump inhibitors) that reduces the amount of acid made by the stomach, thus preventing damage to the stomach. Thus, the combination helps alleviate pain with minimal gastric irritation caused due to Naproxen alone.

Uses of Proxzol 500mg/20mg Tablet

Pain relief.

Medicinal Benefits of Proxzol 500mg/20mg Tablet

ESOMEPRAZOLE+NAPROXEN contains Naproxen and esomeprazole (antacid). Naproxen is an anti-inflammatory (reduce inflammation) and an analgesic (reduce pain) agent that works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that is involved in the production of certain chemical substances (prostaglandins) that cause pain and swelling. This helps reduce mild to moderate pain and inflammation at the injured or damaged site decreasing stiffness in joints. It also treats fibrositis (muscle pain and stiffness), tenosynovitis (swelling of tendons), low back pain, strains, and sprains. NSAIDs such as Naproxen have been reported to cause gastric discomfort, acidity, and risk of stomach ulcers. To reduce gastric discomfort and stomach ulceration risk, it is combined with esomeprazole (is a proton pump inhibitor that inhibits gastric acid secretion) to reduce stomach acid production during long-term treatment for people with pre-existing stomach ulcers or for people having a history of developing stomach ulcers while using NSAIDs. Thus, the combination helps alleviate pain with minimal gastric irritation caused due to Naproxen alone.

Directions for Use

Always take the tablets as prescribed by your doctor. Swallow the tablets as a whole with a glass of water. Do not chew, crush or break the tablets. Do not skip or overdose on medicine. If you miss a dose, continue the next dose at the fixed time.

Side Effects of Proxzol 500mg/20mg Tablet

• Confusion
• Headaches
• Ringing in the ears
• Changes in vision
• Tiredness and feeling sleepy
• Dizziness
• Rashes

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take ESOMEPRAZOLE+NAPROXEN if you are allergic to ESOMEPRAZOLE+NAPROXEN. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may increase the risk of heart attack or stroke and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, are older, are alcoholics, or have multiple diseases. Elderly patients are at greater risk for gastrointestinal bleeding problems so that the doctor can limit their dose. It should not be used by the patient who had undergone recent heart bypass surgery or going to have it. ESOMEPRAZOLE+NAPROXEN is not recommended for pregnant women, especially in the third trimester, as it may cause harm to the baby. Therefore, pregnant or breastfeeding women are advised to consult a doctor before taking ESOMEPRAZOLE+NAPROXEN. ESOMEPRAZOLE+NAPROXEN should not be given to children unless prescribed by a doctor. Do not take any other NSAIDs for pain relief along with ESOMEPRAZOLE+NAPROXEN unless prescribed. Prolonged intake of proton pump inhibitors like esomeprazole may cause brittle bones, so your doctor may recommend the intake of Vitamin D and calcium while using ESOMEPRAZOLE+NAPROXEN. Do not consume alcohol with ESOMEPRAZOLE+NAPROXEN as it may increase the risk of stomach bleeding or ulcer.

Drug Interactions

Drug-Drug Interaction:

ESOMEPRAZOLE+NAPROXEN may have interaction with anti-inflammatory medicines (e.g. aspirin, ibuprofen), blood thinners (e.g. warfarin, rivaroxaban), steroids (e.g. prednisolone), diuretic medicines (e.g. furosemide), medicines used to treat heart problems and high blood pressure-lowering medicines (e.g. propranolol, enalapril, losartan, candesartan), antidepressants (e.g. citalopram), and medicine used to treat rheumatoid arthritis (e.g. methotrexate)

Drug-Disease Interaction:

People with diabetes, stomach ulcer, gastrointestinal bleeding, asthma, kidney, liver, or heart problems, and an autoimmune condition, such as systemic lupus erythematosus (joint pain, fever, and skin rashes), colitis or Crohn’s disease (conditions causing swelling of the bowel, diarrhoea, bowel pain, vomiting, and weight loss) should consult a doctor before taking ESOMEPRAZOLE+NAPROXEN.

Safety Advice

ALCOHOL

You are recommended to avoid alcohol consumption with ESOMEPRAZOLE+NAPROXEN as it may increase the risk of stomach bleeding and ulcer.

PREGNANCY

There is limited data on how ESOMEPRAZOLE+NAPROXEN affects pregnancy. Please consult your doctor if you are planning to become pregnant or already pregnant before starting ESOMEPRAZOLE+NAPROXEN.

BREAST FEEDING

ESOMEPRAZOLE+NAPROXEN passes into the breast milk. However, no evidence of risk has been reported. Please consult your doctor before intake of ESOMEPRAZOLE+NAPROXEN. Your doctor will weigh the benefits and any potential risks before prescribing ESOMEPRAZOLE+NAPROXEN to you.

DRIVING

ESOMEPRAZOLE+NAPROXEN may cause dizziness, tiredness, drowsiness or vision problems in some people. So, drive only if you are alert after taking ESOMEPRAZOLE+NAPROXEN.

LIVER

ESOMEPRAZOLE+NAPROXEN is to be used with caution in people having liver diseases. Dose adjustments may be necessary. So, you should use it only with your doctor's prescription.

 

KIDNEY

ESOMEPRAZOLE+NAPROXEN is not recommended for use in patients with moderate to severe and severe renal impairment. The dose may be adjusted by your doctor as required. So, it should be used only when prescribed by your doctor.