PRODUCT DETAILS

About Natrise 30 Tablet

TOLVAPTAN belongs to a group of medicines called vasopressin V2 receptor antagonist used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, TOLVAPTAN is also used to treat autosomal dominant polycystic kidney disease (ADPKD).
 
TOLVAPTAN contains ‘tolvaptan’ that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations. This decrease in free water is not associated with an increased excretion of sodium or potassium ions, the increase in serum sodium concentration is solely a result of  increased urine production

Uses of Natrise 30 Tablet

Hyponatremia (low levels of sodium) and autosomal dominant polycystic kidney disease (ADPKD).

Medicinal Benefits of Natrise 30 Tablet

TOLVAPTAN belongs to a group of medicines called vasopressin V2 receptor antagonist. TOLVAPTAN is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Besides this, TOLVAPTAN is also used to treat autosomal dominant polycystic kidney disease (ADPKD). TOLVAPTAN works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, TOLVAPTAN slows down the development of cysts in kidneys and reduces the symptoms of the disease. TOLVAPTAN antagonises the effect of vasopressin, this results in an increase in free water clearance and decreases urine osmolality due to increased urinary excretion, thereby increases serum sodium concentrations.

Directions for Use

Take TOLVAPTAN with or without food. Swallow TOLVAPTAN as a whole with a glass of water, do not crush, break or chew the tablet. Based on your medical condition, your doctor will advise for how long you need to take TOLVAPTAN.

Side Effects of Natrise 30 Tablet

• Dizziness
• Headache
• Dry mouth
• Fatigue
• Weakness
• Diarrhoea
• Thirst
• Increased urge to urinate

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug-Drug Interaction:

TOLVAPTAN may have interaction with antibiotic (clarithromycin, telithromycin, sulfamethoxazole, trimethoprim), anti-fungal (ketoconazole, itraconazole), anti-HIV (ritonavir, indinavir, nelfinavir, saquinavir), antidepressant (nefazodone), aldosterone receptor antagonist (spironolactone), angiotensin receptor inhibitor (valsartan, sacubitril), blood thinner (heparin).

Safety Advice

ALCOHOL

Avoid consuming alcohol while taking TOLVAPTAN as it may cause increased dizziness.

DRIVING

TOLVAPTAN may cause dizziness, weakness and tiredness. Do not drive or operate heavy machinery if you feel dizzy.

LIVER

Dose adjustment may be needed. TOLVAPTAN should be used with caution in patients with liver impairment/liver disease.

KIDNEY

Dose adjustment may be needed. TOLVAPTAN should be used with caution in patients with kidney impairment/liver disease.