PRODUCT DETAILS

About Acgran Injection

GRANISETRON belongs to the class of ‘anti-emetic’ drugs, primarily used to treat nausea and vomiting caused by medical treatments, such as chemotherapy or radiation treatment for cancer, etc. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth.

Uses of Acgran Injection

Nausea and vomiting.

Medicinal Benefits of Acgran Injection

GRANISETRON contains an anti-emetic drug, 'Granisetron' that treats nausea and vomiting caused due to cancer treatment (chemotherapy or radiation therapy) or after surgery, etc. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induces nausea and vomiting. GRANISETRON works by blocking the activity of serotonin in the brain and prevent post-operative nausea and vomiting.

Directions for Use

GRANISETRON is available in oral tablet, syrup, and intravenous injection formulations. Tablet: Take GRANISETRON with or without food. Swallow GRANISETRON as a whole with a glass of water, do not chew or break the tablet. Syrup: Shake the syrup bottle well before use. Check the label for directions and take GRANISETRON after meals with a measuring cup in the dose and duration prescribed by the doctor. Intravenous injection: GRANISETRON is administered into the vein as a shot/injection by a nurse or doctor.

Side Effects of Acgran Injection

Diarrhoea

Constipation

Stomach pain

Weakness

Headache

Fever

Dizziness

Drowsiness

Trouble sleeping

Anxiety

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

GRANISETRON may cause serotonin syndrome/toxicity when used with other drugs like ecstasy (MDMA) and antidepressants. Hence it is suggested to seek medical advice if you are using any prescription or non-prescription medicines. Inform your doctor if you have a history of stomach/intestinal problems like stomach ache, wind, feeling or being sick, difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), heart problems and liver or kidney diseases before starting GRANISETRON. GRANISETRON may affect the heart rhythm (QT prolongation) and cause fast/irregular heartbeat, hence check with your doctor before starting GRANISETRON if you have any heart problems. Please consult your doctor if you are pregnant or breastfeeding if the doctor advised you GRANISETRON. GRANISETRON may make you feel dizzy, so drive only if you are alert. Avoid consuming alcohol along with GRANISETRON as it could lead to increased dizziness. GRANISETRON is not recommended in children below two years of age.

Drug Interactions

Drug-Drug Interaction:

GRANISETRON may interact with antidepressants (lithium, fluoxetine, paroxetine, duloxetine, venlafaxine), street drugs (MDMA or 3,4-Methyl?enedioxy?methamphetamine), heart-related drugs (amiodarone, dofetilide, procainamide, quinidine and sotalol), antipsychotic drugs (pimozide), HIV/AIDS drugs (ritonavir), antibiotics (erythromycin) and St. John's wort, a plant-based medicine used for depression and mood disorders.

Drug-Disease Interaction:

Before using GRANISETRON, let your doctor know if you have any stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), heart problems and liver or kidney diseases.

Safety Advice

ALCOHOL

You are recommended to limit or avoid alcohol consumption while taking GRANISETRON. Alcohol intake, along with GRANISETRON, may cause increased dizziness.

PREGNANCY

It is not known if GRANISETRON affects pregnancy. Please consult your doctor if you are pregnant or planning to conceive before using GRANISETRON.

BREAST FEEDING

It is not known if GRANISETRON passes into the breast milk. Please consult your doctor before taking GRANISETRON if you are a nursing mother.

DRIVING

GRANISETRON may make you feel dizzy that affects your mental ability. Do not drive or operate machinery if you experience dizziness.

LIVER

GRANISETRON should be cautiously administered in patients with liver diseases. Please consult your doctor if you have a history of liver impairment before starting GRANISETRON.

KIDNEY

GRANISETRON should be cautiously administered in patients with kidney problems. Please consult your doctor if you have a history of kidney impairment/kidney disease.