PRODUCT DETAILS

About Trigli 2 Tablet SR

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE belongs to the group of medications called ‘antidiabetic agents’ used in the treatment of Type 2 diabetes mellitus. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels rise more than normal. It occurs when the body does not produce enough insulin (metabolizes glucose), or if produced, it cannot function properly in the body.

Uses of Trigli 2 Tablet SR

Type 2 Diabetes Mellitus

Medicinal Benefits of Trigli 2 Tablet SR

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE contains Metformin, Glimepiride, and Pioglitazone. GLIMEPIRIDE+METFORMIN+PIOGLITAZONE is given when single or dual therapy of hypoglycemic agents is not effective in diabetes patients. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Glimepiride acts by increasing the secretion of insulin by the pancreas. Pioglitazone works by decreasing the amount of glucose released by the liver and improving insulin sensitivity in muscle and fat. 

Directions for Use

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE should be swallowed as a whole with a glass of water. Do not crush, chew, or break the tablets. Take the dose as prescribed by your doctor at a fixed time every day.

Side Effects of Trigli 2 Tablet SR

Nausea (feeling sick)

Vomiting (falling sick)

Diarrhea

Headache

Stomach ache

Respiratory infection

Weight gain

Sweating

Palpitations

Numbness

Vision problems

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE should be used with caution in patients with heart diseases as it increases the risk of heart failure. GLIMEPIRIDE+METFORMIN+PIOGLITAZONE may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. It is a life-threatening condition that requires immediate medical attention. Inform your doctor if you have any severe liver or kidney problems as their normal functioning is required to eliminate excess lactic acid from the body. Do not consume excess alcohol as it increases the risk of lactic acidosis. GLIMEPIRIDE+METFORMIN+PIOGLITAZONE may lower vitamin B12 levels, so it is recommended to take blood tests regularly to identify any vitamin deficiencies.

Drug Interactions

Drug-Drug Interaction:

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE may have an interaction with medicines used to treat bacterial infections (rifampicin, tetracycline, and clarithromycin), a medicine used to treat fungal infections (fluconazole), other oral antidiabetics, and medicines used to treat gout (probenecid).

Drug-Disease Interaction:

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE should be avoided in patients with heart diseases (congestive heart failure and myocardial infarction), vitamin B12 deficiency, and alcoholism, type I diabetes, bladder cancer, edema (fluid retention), liver disease, premenopausal anovulation, obesity (weight gain), anemia should avoid intake of GLIMEPIRIDE+METFORMIN+PIOGLITAZONE.

Safety Advice

ALCOHOL

Alcohol may increase the risk of side-effects and worsen the condition.

PREGNANCY

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE is a category C drug and may cause harmful effects to the unborn baby. So, it is used only when the benefits of this medicine outweigh the risks.

BREAST FEEDING

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE should not be used in breastfeeding mothers as it may get secreted in the breast milk and cause unwanted effects in the nursing babies.

DRIVING

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using GLIMEPIRIDE+METFORMIN+PIOGLITAZONE.

LIVER

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE should be taken with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

KIDNEY

GLIMEPIRIDE+METFORMIN+PIOGLITAZONE should be taken with caution especially if you have a history of kidney diseases. The dose may have to be adjusted by your doctor.