PRODUCT DETAILS

About Kombina 400mg/80mg Tablet

SULFAMETHOXAZOLE+TRIMETHOPRIM belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. SULFAMETHOXAZOLE+TRIMETHOPRIM does not work against infections caused by the virus, including cold and flu. 

SULFAMETHOXAZOLE+TRIMETHOPRIM is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, SULFAMETHOXAZOLE+TRIMETHOPRIM kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections.

Uses of Kombina 400mg/80mg Tablet

Bacterial infections

Medicinal Benefits of Kombina 400mg/80mg Tablet

SULFAMETHOXAZOLE+TRIMETHOPRIM belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). SULFAMETHOXAZOLE+TRIMETHOPRIM is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, SULFAMETHOXAZOLE+TRIMETHOPRIM kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. SULFAMETHOXAZOLE+TRIMETHOPRIM is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria such as Streptococcus pneumonia, Escherichia coli, Klebsiella species, Enterobacter species, Haemophilus influenzae, etc.

Directions for Use

Take SULFAMETHOXAZOLE+TRIMETHOPRIM with food or drink to avoid nausea and diarrhoea. However, SULFAMETHOXAZOLE+TRIMETHOPRIM can be taken with or without food. The tablet form of SULFAMETHOXAZOLE+TRIMETHOPRIM should be swallowed as a whole; do not crush or chew the tablet. The liquid form of SULFAMETHOXAZOLE+TRIMETHOPRIM should be taken by mouth using the measuring cup provided by the pack; shake the pack well before each use. The dose and duration of SULFAMETHOXAZOLE+TRIMETHOPRIM can vary depending upon your condition and severity of the infection.

Side Effects of Kombina 400mg/80mg Tablet

Like all medicines, SULFAMETHOXAZOLE+TRIMETHOPRIM can also cause side-effects, although not everybody experiences them. High levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes are the common side-effects of SULFAMETHOXAZOLE+TRIMETHOPRIM. Please consult your doctor if you experience any of these side-effects persistently.

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug-Drug Interaction:

SULFAMETHOXAZOLE+TRIMETHOPRIM may have interaction with sulphonylureas (gliclazide, glibenclamide), thiazide diuretics (bendroflumethiazide), antibiotic (azithromycin, metronidazole), and bronchodilator (albuterol). 

Safety Advice

ALCOHOL

Avoid alcohol consumption while taking SULFAMETHOXAZOLE+TRIMETHOPRIM to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

 

KIDNEY

SULFAMETHOXAZOLE+TRIMETHOPRIM to be taken with caution, especially if you have a history of kidney impairment/kidney disease.