PRODUCT DETAILS

About Actizid 1000mg Tablet

PYRAZINAMIDE belongs to the group of medicines called 'anti-tuberculosis' drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine, and bone marrow. PYRAZINAMIDE does not work against infections caused by the virus, such as the common cold and flu.

PYRAZINAMIDE contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesized bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids, this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

PYRAZINAMIDE is available in oral tablet formulation. Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of PYRAZINAMIDE include muscle/joint pain, nausea, vomiting, and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting PYRAZINAMIDE. Please tell your doctor if you are allergic to PYRAZINAMIDE or its components. Inform your doctor beforehand if you have a history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use, and undergoing dialysis. It is essential to let your doctor know if you are pregnant, planning to conceive, or are a breastfeeding mother. Avoid consuming alcohol along with PYRAZINAMIDE as it might lead to liver problems.

Uses of Actizid 1000mg Tablet

Tuberculosis (TB)

Medicinal Benefits of Actizid 1000mg Tablet

PYRAZINAMIDE contains 'Pyrazinamide', which is used to treat and prevent tuberculosis. Pyrazinamide is a chemically synthesized bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids, this disrupts the cell membrane and disables energy production necessary to survive the TB bacteria. It is usually given in alone or combined with other antitubercular agents to treat tuberculosis.

Directions for Use

PYRAZINAMIDE is available in oral tablet formulation. Tablet: Take PYRAZINAMIDE 30 minutes before food or 2 hours after food. Swallow PYRAZINAMIDE as a whole with a glass of water, do not chew, or break the tablet.

Side Effects of Actizid 1000mg Tablet

• Muscle/joint pain
• Nausea
• Vomiting
• Loss of appetite
• Hepatitis, liver dysfunction

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Brief your medical history if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use, and undergoing dialysis treatment. Please tell your doctor if you are allergic to PYRAZINAMIDE or its components. PYRAZINAMIDE gets converted in the body to Pyrazinoic acid that blocks the excretion of urates (salt form of uric acid) by the kidneys. Increased blood levels of uric acid (hyperuricemia) cause pain, swelling, redness, and stiffness in joints (gout). Hence, PYRAZINAMIDE should be avoided if you have a history of gout. Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since PYRAZINAMIDE may affect the vaccine's activity. PYRAZINAMIDE is released into breast milk and may harm a nursing baby. Please consult your doctor know if you are pregnant, planning to conceive, or are a breastfeeding mother. Avoid consuming alcohol along with PYRAZINAMIDE as it might lead to liver problems. Store PYRAZINAMIDE below 25°C away from direct sunlight.

Drug Interactions

Drug-Drug Interaction:

PYRAZINAMIDE may interact with gout medicine (probenecid, sulfinpyrazone) and oral contraceptives.

Drug-Disease Interaction:

Before using PYRAZINAMIDE, let your doctor know if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use, and undergoing dialysis treatment.

Safety Advice

ALCOHOL

You are recommended to avoid alcohol consumption while taking PYRAZINAMIDE. Alcohol intake, along with PYRAZINAMIDE, may cause increased liver damage. Please consult your doctor for more information.

PREGNANCY

PYRAZINAMIDE is a pregnancy category C drug. So, use it with caution during pregnancy. Please consult your doctor before taking PYRAZINAMIDE if you are pregnant or planning to conceive.

BREAST FEEDING

PYRAZINAMIDE is not recommended for use during breastfeeding since it is excreted into breast milk and may harm a nursing baby. Please consult your doctor if you are a breastfeeding mother.

DRIVING

It is not known if PYRAZINAMIDE alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to drive or operate machinery.

LIVER

PYRAZINAMIDE is contraindicated in patients with severe liver damage. Please consult your doctor since PYRAZINAMIDE should be used with caution in patients with liver impairment/liver disease. Regular monitoring of liver function tests is also advised.

KIDNEY

Please consult your doctor since PYRAZINAMIDE should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.