PRODUCT DETAILS

About Pinerva NP 75mg/10mg/1500mcg Tablet

METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).

METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN helps to treat neuropathic pain.

Uses of Pinerva NP 75mg/10mg/1500mcg Tablet

Neuropathic pain

Medicinal Benefits of Pinerva NP 75mg/10mg/1500mcg Tablet

METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN is a combination of three drugs: Methylcobalamin (a form of vitamin B), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN helps to treat neuropathic pain.

Directions for Use

METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN can be taken with or without food. METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN should be swallowed whole with a glass of water; do not chew or break the tablet. Your doctor will determine how long you need to take METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN based on your medical condition.

Side Effects of Pinerva NP 75mg/10mg/1500mcg Tablet

• Constipation
• Dry mouth
• Headache
• Feeling sleepy, tired or dizzy
• Diarrhoea

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

If you are allergic to any of the ingredients in METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN, do not consume it. Please do not stop taking METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN unless your doctor has prescribed it. METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN may cause drowsiness and dizziness, therefore drive only if you are alert. METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.

Drug Interactions

Drug-Drug Interaction:

METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN may have interaction with antidepressant medications (e.g. duloxetine, sertraline, escitalopram), pain killer medications (e.g. codeine, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant medications (e.g. topiramate), anti-anxiety medications (e.g. alprazolam), sedative-hypnotics medications (e.g. zolpidem), antihistamine medications (e.g. diphenhydramine, cetirizine), muscle relaxant medications (e.g. cyclobenzaprine), antiemetic medications (e.g. ondansetron), and he

Drug-Disease Interaction:

Use METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN with medical advice if you have had anticholinergic effects, cardiovascular disease, pheochromocytoma, acute myocardial infarction recovery, cardiovascular disease, depression, seizure disorders, drug dependence, suicidal tendency, angioedema, creatine kinase elevations, peripheral oedema, PR interval prolongation, bone marrow suppression, diabetes, renal/liver disease, schizophrenia/bipolar disorder, hyper/hypoglycemia, schizophrenia, thyroid disorders and urinary retention.

Safety Advice

ALCOHOL

Avoid consumption of alcohol while taking METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN as it may increase drowsiness and sleepiness.

PREGNANCY

If you're pregnant, don't take METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.

BREAST FEEDING

Consult your doctor as there is no substantial research yet on the use of METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN in breastfeeding/nursing mothers.

DRIVING

METHYLCOBALAMIN+NORTRIPTYLINE+PREGABALIN causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

LIVER

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

KIDNEY

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.