PRODUCT DETAILS

About Leofenac-MR Tablet

ACECLOFENAC+PARACETAMOL+TIZANIDINE is a combination medicine that belongs to the class of medications called 'non-steroidal anti-inflammatory drugs (NSAID)' used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone, joint pain, headache, and period pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.
 
ACECLOFENAC+PARACETAMOL+TIZANIDINE is a combination of three drugs, namely: Tizanidine (muscle relaxant), Aceclofenac (pain killer), and Paracetamol (mild analgesic and fever reducer). Tizanidine is a short-acting muscle relaxant that works on the brain's centers, thereby helping to relieve muscle stiffness and improve muscle movements. Aceclofenac and Paracetamol are analgesics that work by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandin (PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, ACECLOFENAC+PARACETAMOL+TIZANIDINE helps in relieving pain and fever due to muscle spasms.
 
You are advised to take ACECLOFENAC+PARACETAMOL+TIZANIDINE for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, vomiting, stomach pain, loss of appetite, heartburn, and diarrhea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
ACECLOFENAC+PARACETAMOL+TIZANIDINE can increase your risk of fatal heart attack or stroke. So, if you have had any recent heart surgery, do not use ACECLOFENAC+PARACETAMOL+TIZANIDINE. ACECLOFENAC+PARACETAMOL+TIZANIDINE increases the chances of stomach ulcers and bleeding. Do not take ACECLOFENAC+PARACETAMOL+TIZANIDINE if you are pregnant or breastfeeding unless prescribed. ACECLOFENAC+PARACETAMOL+TIZANIDINE causes drowsiness and dizziness, so drive with caution. ACECLOFENAC+PARACETAMOL+TIZANIDINE should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol as it causes increased drowsiness, and dizziness and increases the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Leofenac-MR Tablet

Musculoskeletal pain, Low back pain

Medicinal Benefits of Leofenac-MR Tablet

ACECLOFENAC+PARACETAMOL+TIZANIDINE is a combination of three drugs, namely: Tizanidine, Aceclofenac, and Paracetamol. ACECLOFENAC+PARACETAMOL+TIZANIDINE is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone, and joint pain, headache, and period pain. Tizanidine is a muscle relaxant that works on the centers of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac and Paracetamol are analgesics that work by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins (PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, ACECLOFENAC+PARACETAMOL+TIZANIDINE helps in relieving pain and fever due to muscle spasms.

Directions for Use

Take ACECLOFENAC+PARACETAMOL+TIZANIDINE with or without food. Swallow ACECLOFENAC+PARACETAMOL+TIZANIDINE as a whole with a glass of water; do not chew, or break the table. Based on your medical condition, your doctor will decide how long you need to take ACECLOFENAC+PARACETAMOL+TIZANIDINE.

Side Effects of Leofenac-MR Tablet

• Nausea
• Vomiting
• Stomach pain
• Diarrhea
• Loss of appetite
• Heartburn

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take ACECLOFENAC+PARACETAMOL+TIZANIDINE if you are allergic to any of its contents; if you have/had severe heart problems, stomach ulcer or perforation, and bleeding problems such as bleeding from the stomach, intestine, or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of intestines. ACECLOFENAC+PARACETAMOL+TIZANIDINE can increase your risk of fatal heart attack or stroke. So, if you have had any recent heart surgery, do not take ACECLOFENAC+PARACETAMOL+TIZANIDINE. Inform your doctor before taking ACECLOFENAC+PARACETAMOL+TIZANIDINE if you have had high blood pressure, heart problems, high cholesterol, diabetes, asthma, inflammatory bowel disease, or liver and kidney problems. Do not take ACECLOFENAC+PARACETAMOL+TIZANIDINE if you are pregnant or breastfeeding unless prescribed. ACECLOFENAC+PARACETAMOL+TIZANIDINE may cause drowsiness and dizziness, so drive only if you are alert. ACECLOFENAC+PARACETAMOL+TIZANIDINE is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with ACECLOFENAC+PARACETAMOL+TIZANIDINE as it could lead to increased drowsiness and can increase the risk of stomach bleeding. Stop taking ACECLOFENAC+PARACETAMOL+TIZANIDINE and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach such as blood in stools. Do not take any other NSAIDs for pain relief along with ACECLOFENAC+PARACETAMOL+TIZANIDINE unless prescribed. 

Drug Interactions

Drug-Drug Interaction:

ACECLOFENAC+PARACETAMOL+TIZANIDINE may have interaction with pain killers (aspirin, ibuprofen, naproxen, celecoxib, etoricoxib, hydrocodone), anti-depressants (citalopram, escitalopram, duloxetine, fluoxetine, fluvoxamine, paroxetine, sertraline, lithium), cardiac glycoside (digoxin), anti-hypertensives (enalapril, lisinopril, losartan, candesartan, hydralazine, propranolol), antibiotics (ciprofloxacin, ofloxacin, levofloxacin moxifloxacin), diuretics (furosemide, amiloride hydrochloride), blood thinners (warfarin, heparin, clopidogrel), anti-rheumatoid (methotrexate), steroids (mifepristone), glucocorticoids (hydrocortisone, prednisolone), immunosuppressants (ciclosporin, tacrolimus), anti-HIV (zidovudine), anti-diabetic (glibenclamide, gliclazide, tolbutamide), hypnotic (zolpidem), anti-convulsant (pregabalin), antihistamine (diphenhydramine, cetirizine)

Drug-Disease Interaction:

ACECLOFENAC+PARACETAMOL+TIZANIDINE may have interactions with stomach ulcer or perforation, bleeding problems, bypass surgery, heart attack, blood circulation problems, inflammation of intestines anemia, heart, kidney, and liver problems.

Safety Advice

ALCOHOL

Avoid consumption of alcohol while taking ACECLOFENAC+PARACETAMOL+TIZANIDINE as it may increase drowsiness. It can also increase the risk of stomach bleeding.

PREGNANCY

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

BREAST FEEDING

Consult your doctor before taking ACECLOFENAC+PARACETAMOL+TIZANIDINE; your doctor will decide whether ACECLOFENAC+PARACETAMOL+TIZANIDINE can be taken by breastfeeding mothers or not.

DRIVING

ACECLOFENAC+PARACETAMOL+TIZANIDINE may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

LIVER

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

KIDNEY

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.