PRODUCT DETAILS

About Isedaz Injection

MIDAZOLAM belongs to a class of drugs called benzodiazepines (sedatives) used to induce sleepiness during therapeutic procedures (like endoscopy or colonoscopy) or complicated medical tests known as procedural sedation. Besides this, MIDAZOLAM also treat acute (sudden) repetitive fits (epilepsy). Conscious sedation is a technique in which drugs help you relax (sedative), reduce anxiety and inhibit pain (anaesthetic) during a medical test or procedure. It is usually referred to as procedural sedation and analgesia. Epilepsy (fits) is a disorder in which there is a sudden, uncontrolled disturbance in nerve cells' electrical activity in the brain.

MIDAZOLAM contains Midazolam that works by increasing GABA activity (a chemical messenger in the brain that acts as a natural nerve-calming agent) involved in inducing drowsiness. Thereby, MIDAZOLAM relaxes muscles, reduces anxiety and cause drowsiness. Also, MIDAZOLAM prevents fits by stabilizing the electrical activity of nerve cells in the brain. 

Take MIDAZOLAM as prescribed by your doctor. You are advised to take MIDAZOLAM for as long as your doctor has prescribed it for you based on your medical condition. You may experience nausea, vomiting, headache, drowsiness, runny nose, throat irritation, nasal discomfort, and dizziness in some cases. Most of these side effects of MIDAZOLAM do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to MIDAZOLAM or any other medicines, please tell your doctor. Avoid taking MIDAZOLAM if you are pregnant, especially in the last trimester as it may cause adverse effects in the baby. MIDAZOLAM may be excreted in breastmilk. Therefore, please consult a doctor if you are breastfeeding. MIDAZOLAM should be used with caution in elderly patients as there is an increased risk of adverse effects. Special care should be taken while giving an injection to children, and dose will be adjusted appropriately. Avoid consumption of alcohol with MIDAZOLAM as it may increase the sedative effect of MIDAZOLAM. MIDAZOLAM may cause drowsiness or affect concentration and co-ordination. It is an offence to drive if MIDAZOLAM affects you. Therefore, avoid driving if you feel drowsy after taking MIDAZOLAM. 

Uses of Isedaz Injection

Fits (epilepsy), Procedural sedation

Medicinal Benefits of Isedaz Injection

MIDAZOLAM contains Midazolam used to induce conscious sedation (awake but very relaxed state of calm or drowsiness) during therapeutic procedures or medical tests. Also, MIDAZOLAM is used to treat acute (sudden) repetitive fits. MIDAZOLAM increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent) that is involved in inducing drowsiness. Thereby, MIDAZOLAM relaxes muscles, reduces anxiety and cause drowsiness. Also, MIDAZOLAM prevents fits by stabilizing the electrical activity of nerve cells in the brain.

Directions for Use

The injection form of MIDAZOLAM is given as an intravenous (into a vein) injection or infusion (a drip), intramuscular injection (into a muscle) or injected into the rectum by a doctor or nurse. Do not self-administer injection. The nasal spray form of MIDAZOLAM is only for use in the nose. You are advised to insert the tip of the bottle into the nostril and spray towards the sides of nostril while closing the other nostril. Keep the head straight and breathe gently as you spray. Repeat the same procedure for other nostril. The oromucosal solution of MIDAZOLAM is not to be injected. Place the syringe tip into the back of space between the inside of the cheek and lower gum. Then slowly press the plunger until it stops and insert the full amount of solution into the buccal cavity (space between gum and cheek).

Side Effects of Isedaz Injection

• Nausea
• Vomiting
• Headache
• Drowsiness
• Runny nose
• Throat irritation
• Nasal discomfort
• Dizziness

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

If you are allergic to MIDAZOLAM or any other medicines, please tell your doctor. Avoid taking MIDAZOLAM if you are pregnant, especially in the last trimester as it may cause adverse effects in the baby. MIDAZOLAM may be excreted in breastmilk. Therefore, please consult a doctor if you are breastfeeding. MIDAZOLAM should be used with caution in elderly patients as there is an increased risk of adverse effects. Special care should be taken while giving an injection to children, and dose will be adjusted appropriately. Avoid consumption of alcohol with MIDAZOLAM as it may increase the sedative effect of MIDAZOLAM. MIDAZOLAM may cause drowsiness or affect concentration and co-ordination. It is an offence to drive if MIDAZOLAM affects you. Therefore, avoid driving if you feel drowsy after taking MIDAZOLAM. If you have chronic respiratory problems, myasthenia gravis (muscle weakness), history of drug abuse or depression, narrow-angle glaucoma, sleep apnoea syndrome (sleep disorder in which breathing stops and starts repeatedly), kidney, liver or heart problems, inform your doctor before taking MIDAZOLAM. Do not take MIDAZOLAM with opioids until and unless prescribed by a doctor as it may increase the risk of difficulties in breathing, drowsiness or coma.

Drug Interactions

Drug-Drug Interaction:

MIDAZOLAM may have interaction with high blood pressure-lowering medicines (diltiazem, verapamil), antifungals (fluconazole, ketoconazole, voriconazole, itraconazole, posaconazole), antibiotics (clarithromycin, erythromycin, rifampicin), high cholesterol-lowering medicines (atorvastatin), medicines for HIV/AIDS (saquinavir, lopinavir/ritonavir), anticonvulsants (phenytoin, levetiracetam, lamotrigine), anti-ulcer drugs (cimetidine, omeprazole, ranitidine), opioid pain killers (fentanyl), anti-allergic drugs (diphenhydramine), antianxiety drug (clobazam, alprazolam, diazepam, valium, xanax), water tablet (furosemide).

Drug-Disease Interaction:

If you have chronic respiratory problems, myasthenia gravis (muscle weakness), history of drug abuse or depression, narrow-angle glaucoma, sleep apnoea syndrome (sleep disorder in which breathing stops and starts repeatedly), kidney, liver or heart problems, inform your doctor before taking MIDAZOLAM.

Safety Advice

ALCOHOL

Avoid consumption of alcohol with MIDAZOLAM as it may increase the sedative effect of MIDAZOLAM.

PREGNANCY

MIDAZOLAM is a Category D pregnancy drug and is not recommended for pregnant women, especially in the last 3 months of pregnancy as it may cause adverse effects in the baby. Please consult a doctor if you are pregnant or planning for pregnancy.

BREAST FEEDING

MIDAZOLAM may be excreted in human milk. Please consult a doctor if you are breastfeeding. However, avoid breastfeeding for 24 hours after taking MIDAZOLAM.

DRIVING

MIDAZOLAM may cause drowsiness or affect concentration and co-ordination. It is an offence to drive if MIDAZOLAM affects you. Therefore, avoid driving if you feel drowsy after taking MIDAZOLAM.

LIVER

Take MIDAZOLAM with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

KIDNEY

If you have any concerns regarding the use of MIDAZOLAM in patients with kidney problems, please consult a doctor.