PRODUCT DETAILS

About Domipen 10mg Tablet

DOMPERIDONE belongs to a class of medications known as 'dopamine antagonists used to treat nausea (feeling sick) and vomiting (being sick) in adults and adolescents 12 years or older. Besides this, it also helps in the treatment of indigestion. Nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying).

DOMPERIDONE prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting center (chemoreceptor trigger zone – CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time.

It is better to take DOMPERIDONE before meals, as when taken after meals, the absorption of the medicine is slightly delayed. Symptoms of nausea and vomiting may usually resolve within 3-4 days after taking DOMPERIDONE. However, if it does not resolve even after this, stop taking this medicine and contact the doctor. Do not take DOMPERIDONE for longer than seven days. The most common side effect of DOMPERIDONE is dry mouth. These side effects are temporary and may resolve after some time; however, if this side persists, contact the doctor. Try to avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes). Before taking DOMPERIDONE, contact your doctor if you suffer from liver problems, or kidney problems (kidney function impairment or failure).

Prolonged intake of DOMPERIDONE may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking doses higher than 30 mg per day. Tell your doctor if you are using any anti-fungal medicines and/or if you have heart problems or AIDS/HIV. If you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking DOMPERIDONE, immediately contact your doctor. Adolescents (children from 12-18 years of age) who are weighing less than 35 kg should not be given DOMPERIDONE.

Uses of Domipen 10mg Tablet

Prevention of Nausea, Prevention of Vomiting

Medicinal Benefits of Domipen 10mg Tablet

DOMPERIDONE contains domperidone, which is a dopamine antagonist that helps by blocking certain vomiting-inducing receptors in the brain. DOMPERIDONE also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and decreases gastric emptying time.

Directions for Use

It is better to take DOMPERIDONE 15-30 minutes before a meal. DOMPERIDONE should be swallowed whole with a glass of water. Do not chew, crush, or break it. Besides this, DOMPERIDONE is also available in liquid form for those who cannot swallow tablets or capsules. Do not take DOMPERIDONE for more than 7 days.

Side Effects of Domipen 10mg Tablet

Every medicine has its own side effects. Likewise, DOMPERIDONE has the common side effects of dry mouth. This side effect is temporary and may resolve after some time; however, if this side effect persists, contact the doctor.

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Prolonged intake of DOMPERIDONE may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking doses higher than 30 mg per day. Tell your doctor if you are using any anti-fungal medicines and/or if you have heart problems or AIDS/HIV. If you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking DOMPERIDONE, immediately contact your doctor. Adolescents (children from 12-18 years of age) who are weighing less than 35 kg should not be given DOMPERIDONE.

Drug Interactions

Drug-Drug Interaction:

DOMPERIDONE should not be taken with medicines used to treat heart problems or high blood pressure (amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol, diltiazem, verapamil), depression (citalopram, escitalopram),  anti-cancer agents (toremifene, vandetanib, vincamine), bacterial infections (specifically erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine), gastrointestinal disorders (cisapride, dolasetron, prucalopride), antimalarial (halofantrine), neuro-related medicines ( haloperidol, pimozide, sertindole), antifungal ( ketoconazole, fluconazole, voriconazole), gastrointestinal drugs ( cisapride, dolasetron, prucalopride) and anti-HIV drugs.

Drug-Disease Interaction:

DOMPERIDONE should not be taken in patients with liver disease,  brain tumors, history of gastrointestinal bleeding, or any problem involving the bowels.

Safety Advice

ALCOHOL

Drinking alcohol with DOMPERIDONE may cause sleepiness or an irregular heartbeat.

PREGNANCY

DOMPERIDONE is not usually recommended in pregnancy.

BREAST FEEDING

DOMPERIDONE is not usually recommended when breastfeeding, as it passes into breast milk in small amounts. Talk to a doctor, as other medicines might be better.

DRIVING

DOMPERIDONE can make you feel sleepy and confused, so operating machinery or driving a car should be avoided as it may impair your ability to concentrate.

LIVER

DOMPERIDONE should be taken with precaution in patients with liver disease.

KIDNEY

DOMPERIDONE should be taken with caution in patients with kidney problems. Your doctor will adjust your dose depending upon the condition of your disease.