PRODUCT DETAILS

About Domax Plus 10mg/500mg Tablet

DOMPERIDONE+PARACETAMOL is a combination medicine used for the symptomatic treatment of migraine, and any medical condition with concomitant nausea/vomiting and fever/pain. Migraine is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head, eyes, face, and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

DOMPERIDONE+PARACETAMOL is a combination of two drugs, namely: Domperidone and Paracetamol. Domperidone prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting center (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

DOMPERIDONE+PARACETAMOL is available in both oral tablet and suspension dosage forms. It is advised to take DOMPERIDONE+PARACETAMOL 25-30 minutes before a meal. Your doctor will recommend how often you take DOMPERIDONE+PARACETAMOL based on your medical condition.  Some people may experience some side effects, dry mouth, skin rash, anxiety, diarrhea, and drowsiness. Most of these side effects of DOMPERIDONE+PARACETAMOL do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

You can increase the efficacy of DOMPERIDONE+PARACETAMOL by taking a small meal or snacks frequently. Do not take DOMPERIDONE+PARACETAMOL if you are allergic to DOMPERIDONE+PARACETAMOL and other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking DOMPERIDONE+PARACETAMOL. Inform your doctor if you have heart, kidney, and liver disease. Prolonged intake of DOMPERIDONE+PARACETAMOL may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you experience heart rhythm disorders like palpitations, trouble breathing, or loss of consciousness after taking DOMPERIDONE+PARACETAMOL, immediately contact your doctor.

Uses of Domax Plus 10mg/500mg Tablet

Migraine

Medicinal Benefits of Domax Plus 10mg/500mg Tablet

DOMPERIDONE+PARACETAMOL is a combination of two drugs namely; Domperidone and Paracetamol used to treat vomiting and pain in people with migraines. Domperidone belongs to a class of prokinetic agents that prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting center (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. DOMPERIDONE+PARACETAMOL together is used to prevent nausea, vomiting, pain, and fever associated with migraine.

Directions for Use

Oral Tablet: Take DOMPERIDONE+PARACETAMOL 15-30 minutes before a meal or as advised by your doctor and swallow, it whole with a glass of water. Do not crush, chew, or break it. Oral Suspension: Shake the bottle well before use. Check the label for directions and take DOMPERIDONE+PARACETAMOL with or without food in doses as prescribed by your doctor with the help of a measuring cup.

Side Effects of Domax Plus 10mg/500mg Tablet

Like all medicine, DOMPERIDONE+PARACETAMOL can cause some side effects such as dry mouth, skin rash, anxiety, diarrhea, and drowsiness. Most of these side effects of DOMPERIDONE+PARACETAMOL do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take DOMPERIDONE+PARACETAMOL if you are allergic to any of its contents or any other medicines, have a history of gastrointestinal bleeding, heart disease, or liver/ kidney problem. Prolonged intake of DOMPERIDONE+PARACETAMOL may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). So, if you experience heart rhythm disorders like palpitations, trouble breathing, or loss of consciousness after taking DOMPERIDONE+PARACETAMOL, immediately contact your doctor. This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you are pregnant or breastfeeding, inform your doctor before using DOMPERIDONE+PARACETAMOL. Avoid consumption of alcohol while using DOMPERIDONE+PARACETAMOL as it may increase the side effects and make worse your condition. DOMPERIDONE+PARACETAMOL should not be given to children below five years of age. The use of DOMPERIDONE+PARACETAMOL is safe in children above five years of age if prescribed by the doctor. Do not exceed the dose of paracetamol of more than 4 gm per day as it can damage your liver.

Drug Interactions

Drug-Drug Interaction:

 DOMPERIDONE+PARACETAMOL interact with medicines used to treat heart problems (amiodarone, dronedarone, quinidine, sotalol, diltiazem, verapamil), antibiotics (erythromycin, clarithromycin, moxifloxacin), gastrointestinal disorder (cisapride, dolasetron), blood thinners (warfarin), vomiting and nausea related pills (metoclopramide), and bile related medicines (cholestyramine),

Drug-Disease Interaction:

The use of DOMPERIDONE+PARACETAMOL is restricted in people with liver disease, a history of gastrointestinal bleeding, or any problem involving the bowels.

Safety Advice

ALCOHOL

Alcohol consumption with DOMPERIDONE+PARACETAMOL may cause sleepiness or an irregular heartbeat.

PREGNANCY

The safety of pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

BREAST FEEDING

DOMPERIDONE+PARACETAMOL is not usually recommended when breastfeeding, as it passes into breast milk in a small amount. Therefore, it is given to breastfeeding women only if the doctor thinks the benefits outweigh the risks.

DRIVING

• Drive and operate machinery only if you are alert.

LIVER

DOMPERIDONE+PARACETAMOL is to be taken with caution, especially if you have had a history of liver disease/condition. The dose may have to be adjusted by your doctor.

KIDNEY

DOMPERIDONE+PARACETAMOL is to be taken with caution, especially if you have had a history of kidney disease/condition. The dose may have to be adjusted by your doctor.